Estimation of inhibitory quotient using a comparative equilibrium dialysis assay for prediction of viral response to hepatitis C virus inhibitors.

Mo, H; Yang, C; Wang, K; Wang, Y; Huang, M; Murray, B; Qi, X; Sun, S-C; Deshpande, M; Rhodes, G; Miller, M D

Mo, H; Yang, C; Wang, K; Wang, Y; Huang, M; Murray, B; Qi, X; Sun, S-C; Deshpande, M; Rhodes, G; Miller, M D.

Affiliation

Mo H; Department of Clinical Virology, Gilead Sciences Inc., Foster City, CA, USA. Hongmei.Mo@gilead.com

J Viral Hepat ; 18(5): 338-48, 2011 May.

Article in En | MEDLINE | ID: mdl-20456634

Subject(s)

Antiviral Agents/pharmacology; Hepacivirus/drug effects; Hepatitis C/drug therapy; Protease Inhibitors/pharmacology; Viral Load/drug effects; Antiviral Agents/pharmacokinetics; Antiviral Agents/therapeutic use; Blood Proteins/metabolism; Carbamates/pharmacokinetics; Carbamates/pharmacology; Carbamates/therapeutic use; Cell Line; Comparative Effectiveness Research; Dialysis/methods; Hepacivirus/genetics; Hepacivirus/pathogenicity; Hepatitis C/virology; Humans; Inhibitory Concentration 50; Macrocyclic Compounds/pharmacokinetics; Macrocyclic Compounds/pharmacology; Macrocyclic Compounds/therapeutic use; Membranes, Artificial; Oligopeptides/pharmacokinetics; Oligopeptides/pharmacology; Oligopeptides/therapeutic use; Phenylthiourea/analogs & derivatives; Phenylthiourea/pharmacokinetics; Phenylthiourea/pharmacology; Phenylthiourea/therapeutic use; Plasma/virology; Proline/analogs & derivatives; Proline/pharmacokinetics; Proline/pharmacology; Proline/therapeutic use; Protease Inhibitors/pharmacokinetics; Protease Inhibitors/therapeutic use; Protein Binding/drug effects; Quinolines/pharmacokinetics; Quinolines/pharmacology; Quinolines/therapeutic use; RNA, Viral/blood; Thiazoles/pharmacokinetics; Thiazoles/pharmacology; Thiazoles/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Hepatitis C / Hepacivirus / Viral Load Type of study: Prognostic_studies / Risk_factors_studies Language: En Year: 2011 Type: Article

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