Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic.
Int J Tuberc Lung Dis
; 14(6): 782-5, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20487620
ABSTRACT
Multidrug-resistant (MDR) strains were identified in 40% of 54 strains from patients presenting with tuberculosis (TB) treatment failure or relapse in Bangui, Central African Republic. Results obtained with the MTBDRplus line-probe assay or rpoB sequencing were 86% concordant with rifampicin (RMP) resistant phenotypes, while the amplification refractory mutation system test was 71% concordant. No mutation was found in RMP-susceptible strains. MTBDRplus and sequencing were concordant with the detection of the S315T mutation in katG in 95% of MDR strains. Sequencing of pncA suggested pyrazinamide resistance in 50% of MDR strains. Knowledge of these resistances should help to implement treatment in low-income countries.
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Database:
MEDLINE
Main subject:
DNA, Bacterial
/
Tuberculosis, Multidrug-Resistant
/
Drug Resistance, Multiple, Bacterial
/
Mutation
/
Mycobacterium tuberculosis
/
Antitubercular Agents
Type of study:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Africa
Language:
En
Year:
2010
Type:
Article