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Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.
Eck, Wolfgang; Nicholson, Anthony I; Zentgraf, Hanswalter; Semmler, Wolfhard; Bartling, Sönke.
Affiliation
  • Eck W; Applied Physical Chemistry, University of Heidelberg, Heidelberg, Germany. w-eck@uni-hd.de
Nano Lett ; 10(7): 2318-22, 2010 Jul 14.
Article in En | MEDLINE | ID: mdl-20496900
ABSTRACT
Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.
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Full text: 1 Database: MEDLINE Main subject: Tomography, X-Ray Computed / CD4 Antigens / Contrast Media / Nanoparticles / Gold / Lymph Nodes / Antibodies Limits: Animals Language: En Year: 2010 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Tomography, X-Ray Computed / CD4 Antigens / Contrast Media / Nanoparticles / Gold / Lymph Nodes / Antibodies Limits: Animals Language: En Year: 2010 Type: Article