Impact of differential P450c17 phosphorylation by cAMP stimulation and by starvation conditions on enzyme activities and androgen production in NCI-H295R cells.

Kempná, Petra; Hirsch, Andrea; Hofer, Gaby; Mullis, Primus E; Flück, Christa E

Kempná, Petra; Hirsch, Andrea; Hofer, Gaby; Mullis, Primus E; Flück, Christa E.

Affiliation

Kempná P; Department of Pediatrics, Division of Pediatric Endocrinology, Diabetology and Metabolism, University of Bern, 3010 Bern, Switzerland.

Endocrinology ; 151(8): 3686-96, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20534731

Subject(s)

Adrenal Cortex/metabolism; Androgens/metabolism; Cyclic AMP/pharmacology; Starvation/metabolism; Steroid 17-alpha-Hydroxylase/metabolism; Adrenal Cortex/drug effects; Animals; COS Cells; Cell Line; Chlorocebus aethiops; Cyclic AMP-Dependent Protein Kinases/metabolism; Enzyme Activation/drug effects; Enzyme Activation/physiology; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Enzymologic/physiology; Humans; Phosphorylation/drug effects; Starvation/physiopathology; Steroid 17-alpha-Hydroxylase/genetics; Transfection

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Full text: 1 Database: MEDLINE Main subject: Starvation / Steroid 17-alpha-Hydroxylase / Adrenal Cortex / Cyclic AMP / Androgens Limits: Animals / Humans Language: En Year: 2010 Type: Article

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