T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

Smith, Elizabeth M; Sorota, Steve; Kim, Hyunjin M; McKittrick, Brian A; Nechuta, Terry L; Bennett, Chad; Knutson, Chad; Burnett, Duane A; Kieselgof, Jane; Tan, Zheng; Rindgen, Diane; Bridal, Terry; Zhou, Xiaoping; Jia, Yu-Ping; Dong, Zoe; Mullins, Debbie; Zhang, Xiaoping; Priestley, Tony; Correll, Craig C; Tulshian, Deen; Czarniecki, Michael; Greenlee, William J

Smith, Elizabeth M; Sorota, Steve; Kim, Hyunjin M; McKittrick, Brian A; Nechuta, Terry L; Bennett, Chad; Knutson, Chad; Burnett, Duane A; Kieselgof, Jane; Tan, Zheng; Rindgen, Diane; Bridal, Terry; Zhou, Xiaoping; Jia, Yu-Ping; Dong, Zoe; Mullins, Debbie; Zhang, Xiaoping; Priestley, Tony; Correll, Craig C; Tulshian, Deen; Czarniecki, Michael; Greenlee, William J.

Affiliation

Smith EM; Department of Medicinal Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, USA. elizabeth.m.smith@spcorp.com

Bioorg Med Chem Lett ; 20(15): 4602-6, 2010 Aug 01.

Article in En | MEDLINE | ID: mdl-20580233

Subject(s)

Azetidines/chemistry; Calcium Channel Blockers/chemical synthesis; Calcium Channels, T-Type/chemistry; Piperidines/chemistry; Spiro Compounds/chemistry; Animals; Azetidines/chemical synthesis; Azetidines/therapeutic use; Calcium Channel Blockers/chemistry; Calcium Channel Blockers/therapeutic use; Calcium Channels, T-Type/metabolism; Drug Design; Humans; Pain/drug therapy; Protein Binding; Rats; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Piperidines / Spiro Compounds / Azetidines / Calcium Channel Blockers / Calcium Channels, T-Type Limits: Animals / Humans Language: En Year: 2010 Type: Article

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