Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers.

van der Post, R S; Kiemeney, L A; Ligtenberg, M J L; Witjes, J A; Hulsbergen-van de Kaa, C A; Bodmer, D; Schaap, L; Kets, C M; van Krieken, J H J M; Hoogerbrugge, N

van der Post, R S; Kiemeney, L A; Ligtenberg, M J L; Witjes, J A; Hulsbergen-van de Kaa, C A; Bodmer, D; Schaap, L; Kets, C M; van Krieken, J H J M; Hoogerbrugge, N.

Affiliation

van der Post RS; Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

J Med Genet ; 47(7): 464-70, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20591884

Subject(s)

Colorectal Neoplasms, Hereditary Nonpolyposis/complications; Genetic Predisposition to Disease; MutS Homolog 2 Protein/genetics; Urinary Bladder Neoplasms/genetics; Adaptor Proteins, Signal Transducing/metabolism; Adult; Aged; Carcinoma/complications; Carcinoma/genetics; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein/metabolism; Mutation; Nuclear Proteins/metabolism; Pedigree; Risk Factors; Urinary Bladder Neoplasms/complications; Urothelium

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Full text: 1 Database: MEDLINE Main subject: Urinary Bladder Neoplasms / Colorectal Neoplasms, Hereditary Nonpolyposis / Genetic Predisposition to Disease / MutS Homolog 2 Protein Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2010 Type: Article

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