Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

Toiber, Debra; Azkona, Garikoitz; Ben-Ari, Shani; Torán, Nuria; Soreq, Hermona; Dierssen, Mara

Toiber, Debra; Azkona, Garikoitz; Ben-Ari, Shani; Torán, Nuria; Soreq, Hermona; Dierssen, Mara.

Affiliation

Toiber D; Department of Biological Chemistry and Interdisciplinary Center for Neuronal Computation (ICNC), The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Neurobiol Dis ; 40(1): 348-59, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20600907

Subject(s)

Alternative Splicing/genetics; Cerebral Cortex/metabolism; Cerebral Cortex/pathology; Down Syndrome/genetics; Down Syndrome/metabolism; Gene Dosage/genetics; Genetic Engineering/methods; Protein Serine-Threonine Kinases/genetics; Protein-Tyrosine Kinases/genetics; Acetylcholinesterase/genetics; Animals; Cells, Cultured; Cerebral Cortex/embryology; Down Syndrome/embryology; Female; Gene Expression Regulation, Developmental/genetics; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Serine-Threonine Kinases/physiology; Protein-Tyrosine Kinases/physiology; RNA Splicing/genetics; Dyrk Kinases

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Genetic Engineering / Cerebral Cortex / Protein Serine-Threonine Kinases / Alternative Splicing / Down Syndrome / Gene Dosage Type of study: Guideline / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2010 Type: Article

Fulltext

XML

PubMed Links

Search on Google