Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

Yau, Wai-Lok; Blisnick, Thierry; Taly, Jean-François; Helmer-Citterich, Manuela; Schiene-Fischer, Cordelia; Leclercq, Olivier; Li, Jing; Schmidt-Arras, Dirk; Morales, Miguel A; Notredame, Cedric; Romo, Daniel; Bastin, Philippe; Späth, Gerald F

Yau, Wai-Lok; Blisnick, Thierry; Taly, Jean-François; Helmer-Citterich, Manuela; Schiene-Fischer, Cordelia; Leclercq, Olivier; Li, Jing; Schmidt-Arras, Dirk; Morales, Miguel A; Notredame, Cedric; Romo, Daniel; Bastin, Philippe; Späth, Gerald F.

Affiliation

Yau WL; G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France.

PLoS Negl Trop Dis ; 4(6): e729, 2010 Jun 29.

Article in En | MEDLINE | ID: mdl-20614016

Subject(s)

Cyclophilins/physiology; Cyclosporine/pharmacology; Leishmania donovani/drug effects; Protozoan Proteins/physiology; Amino Acid Sequence; Animals; Binding Sites; Cells, Cultured; Cluster Analysis; Computational Biology; Cyclophilins/genetics; Cyclophilins/metabolism; Gene Expression; Genome, Protozoan; Heat-Shock Response; Humans; Leishmania donovani/genetics; Leishmania donovani/growth & development; Life Cycle Stages; Models, Molecular; Molecular Sequence Data; Phylogeny; Protozoan Proteins/genetics; Protozoan Proteins/metabolism; Sequence Alignment

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Full text: 1 Database: MEDLINE Main subject: Leishmania donovani / Protozoan Proteins / Cyclosporine / Cyclophilins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2010 Type: Article

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