Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.

Lázár-Molnár, Eszter; Chen, Bing; Sweeney, Kari A; Wang, Emilie J; Liu, Weijun; Lin, Juan; Porcelli, Steven A; Almo, Steven C; Nathenson, Stanley G; Jacobs, William R

Lázár-Molnár, Eszter; Chen, Bing; Sweeney, Kari A; Wang, Emilie J; Liu, Weijun; Lin, Juan; Porcelli, Steven A; Almo, Steven C; Nathenson, Stanley G; Jacobs, William R.

Affiliation

Lázár-Molnár E; Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Proc Natl Acad Sci U S A ; 107(30): 13402-7, 2010 Jul 27.

Article in En | MEDLINE | ID: mdl-20624978

Subject(s)

Antigens, Surface/immunology; Apoptosis Regulatory Proteins/immunology; Lung/immunology; Mycobacterium tuberculosis/immunology; Tuberculosis/immunology; Animals; Antigens, Surface/genetics; Apoptosis Regulatory Proteins/deficiency; Apoptosis Regulatory Proteins/genetics; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; B-Lymphocytes/pathology; Female; Flow Cytometry; Gene Expression Profiling; Host-Pathogen Interactions/immunology; Immunohistochemistry; Interleukin-1/metabolism; Interleukin-17/metabolism; Lung/metabolism; Lung/pathology; Lymphocyte Count; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mycobacterium tuberculosis/physiology; Necrosis; Oligonucleotide Array Sequence Analysis; Pneumonia/immunology; Pneumonia/metabolism; Pneumonia/microbiology; Programmed Cell Death 1 Receptor; Survival Rate; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; T-Lymphocytes/pathology; Tuberculosis/microbiology; Tuberculosis/mortality; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Database: MEDLINE Main subject: Tuberculosis / Apoptosis Regulatory Proteins / Lung / Mycobacterium tuberculosis / Antigens, Surface Type of study: Diagnostic_studies Language: En Year: 2010 Type: Article

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