Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Green, Michael R; Monti, Stefano; Rodig, Scott J; Juszczynski, Przemyslaw; Currie, Treeve; O'Donnell, Evan; Chapuy, Bjoern; Takeyama, Kunihiko; Neuberg, Donna; Golub, Todd R; Kutok, Jeffery L; Shipp, Margaret A

Green, Michael R; Monti, Stefano; Rodig, Scott J; Juszczynski, Przemyslaw; Currie, Treeve; O'Donnell, Evan; Chapuy, Bjoern; Takeyama, Kunihiko; Neuberg, Donna; Golub, Todd R; Kutok, Jeffery L; Shipp, Margaret A.

Affiliation

Green MR; Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Blood ; 116(17): 3268-77, 2010 Oct 28.

Article in En | MEDLINE | ID: mdl-20628145

Subject(s)

Antigens, CD/genetics; Chromosomes, Human, Pair 9/genetics; Gene Dosage; Hodgkin Disease/genetics; Janus Kinase 2/genetics; Lymphoma, Large B-Cell, Diffuse/genetics; B7-H1 Antigen; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins/genetics; Janus Kinase 2/antagonists & inhibitors; Janus Kinase 2/metabolism; Programmed Cell Death 1 Ligand 2 Protein; Tumor Cells, Cultured

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Full text: 1 Database: MEDLINE Main subject: Chromosomes, Human, Pair 9 / Hodgkin Disease / Antigens, CD / Lymphoma, Large B-Cell, Diffuse / Gene Dosage / Janus Kinase 2 Type of study: Prognostic_studies Limits: Humans Language: En Year: 2010 Type: Article

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