In vitro and in vivo activities of linezolid alone and combined with vancomycin and imipenem against Staphylococcus aureus with reduced susceptibility to glycopeptides.

Ribes, S; Pachón-Ibáñez, M E; Domínguez, M A; Fernández, R; Tubau, F; Ariza, J; Gudiol, F; Cabellos, C

Ribes, S; Pachón-Ibáñez, M E; Domínguez, M A; Fernández, R; Tubau, F; Ariza, J; Gudiol, F; Cabellos, C.

Affiliation

Ribes S; Laboratory of Experimental Infection, Infectious Diseases Department, IDIBELL-Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. sribes@med.uni-goettingen.de

Eur J Clin Microbiol Infect Dis ; 29(11): 1361-7, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20680368

Subject(s)

Acetamides/pharmacology; Acetamides/therapeutic use; Imipenem/pharmacology; Oxazolidinones/pharmacology; Oxazolidinones/therapeutic use; Staphylococcal Infections/drug therapy; Staphylococcus aureus/drug effects; Vancomycin/pharmacology; Acetamides/pharmacokinetics; Animals; Ascitic Fluid/microbiology; Bacteremia/drug therapy; Bacteremia/microbiology; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Glycopeptides/pharmacology; Glycopeptides/therapeutic use; Imipenem/pharmacokinetics; Imipenem/therapeutic use; Linezolid; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus/drug effects; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Oxazolidinones/pharmacokinetics; Peritonitis/drug therapy; Peritonitis/microbiology; Staphylococcal Infections/microbiology; Vancomycin/pharmacokinetics; Vancomycin/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Staphylococcal Infections / Staphylococcus aureus / Vancomycin / Imipenem / Oxazolidinones / Acetamides Limits: Animals Language: En Year: 2010 Type: Article

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