A new functional role of HIV-1 integrase during uncoating of the viral core.

Briones, Marisa S; Chow, Samson A

Briones, Marisa S; Chow, Samson A.

Affiliation

Briones MS; Department of Molecular and Medical Pharmacology, Molecular Biology Institute, 650 Charles E. Young Drive, Los Angeles, CA 90095, USA.

Immunol Res ; 48(1-3): 14-26, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20721640

ABSTRACT

ABSTRACT

An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.

Subject(s)

Carrier Proteins/metabolism; Cyclophilin A/metabolism; HIV Infections/immunology; HIV Integrase/metabolism; HIV-1/physiology; Virus Integration; Antiviral Restriction Factors; Capsid Proteins/metabolism; HIV Infections/virology; HIV-1/pathogenicity; Host-Pathogen Interactions; Humans; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Viral Core Proteins/metabolism; Virus Replication

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Full text: 1 Database: MEDLINE Main subject: Carrier Proteins / HIV Infections / HIV-1 / Virus Integration / HIV Integrase / Cyclophilin A Limits: Humans Language: En Year: 2010 Type: Article

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