Amidohydrolases/deficiency; Amidohydrolases/genetics; Hepatomegaly/enzymology; Hepatomegaly/genetics; Liver Neoplasms, Experimental/enzymology; Liver Neoplasms, Experimental/genetics; Point Mutation; Amidohydrolases/chemistry; Amidohydrolases/metabolism; Amino Acid Sequence; Animals; Female; Genes, Tumor Suppressor; Hepatocytes/enzymology; Hepatomegaly/etiology; Liver Neoplasms, Experimental/etiology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutant Proteins/chemistry; Mutant Proteins/genetics; Mutant Proteins/metabolism; Phenotype; RNA, Messenger/genetics; RNA, Messenger/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Homology, Amino Acid; Thrombocytosis/enzymology; Thrombocytosis/genetics; Thrombopoietin/biosynthesis; Urate Oxidase/metabolism; Uric Acid/metabolism; Uric Acid/toxicity