Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer's disease.

Araújo, Jocley Queiroz; Lima, Josélia Alencar; Pinto, Angelo da Cunha; de Alencastro, Ricardo Bicca; Albuquerque, Magaly Girão

Araújo, Jocley Queiroz; Lima, Josélia Alencar; Pinto, Angelo da Cunha; de Alencastro, Ricardo Bicca; Albuquerque, Magaly Girão.

Affiliation

Araújo JQ; Instituto de Química (IQ), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. jocleymol@yahoo.com.br

J Mol Model ; 17(6): 1401-12, 2011 Jun.

Article in En | MEDLINE | ID: mdl-20844909

Subject(s)

Acetylcholinesterase/chemistry; Alzheimer Disease/drug therapy; Cholinesterase Inhibitors/chemistry; Indole Alkaloids/chemistry; Binding Sites; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Molecular Conformation; Protein Binding; Protein Conformation

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Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Cholinesterase Inhibitors / Indole Alkaloids / Alzheimer Disease Limits: Humans Language: En Year: 2011 Type: Article

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