Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat.
Eur J Pharmacol
; 191(3): 485-8, 1990 Dec 04.
Article
in En
| MEDLINE
| ID: mdl-2086252
ABSTRACT
Macroscopic jejunal damage and plasma leakage induced within 15 min by E. coli lipopolysaccharide (LPS 50 mg kg-1 i.v.) in the rat was enhanced by the inhibitor of nitric oxide (NO) formation, NG-monomethyl-L-arginine (L-NMMA 50 mg kg-1 i.v.). The nitro-vasodilator, S-nitroso-N-acetyl-penicillamine (SNAP; 10 micrograms kg-1 min-1 i.v.), which generates NO, attenuated both LPS-induced intestinal damage and the enhancement of such damage and plasma leakage produced by L-NMMA. Endogenous NO may thus have a protective role in the intestinal vasculature that can be mimicked by generators of NO.
Search on Google
Database:
MEDLINE
Main subject:
Penicillamine
/
Vasodilator Agents
/
Endotoxins
/
Intestinal Diseases
Limits:
Animals
Language:
En
Year:
1990
Type:
Article