Cyclophilin A/metabolism; Cyclosporine/pharmacology; Drug Resistance, Viral; Gene Expression Regulation, Viral; Hepacivirus/drug effects; Hepacivirus/metabolism; Hepatitis C/drug therapy; Amino Acid Sequence; Blotting, Western; Cell Line; Circular Dichroism; Cyclophilin A/genetics; Enzyme-Linked Immunosorbent Assay; Hepacivirus/genetics; Hepatitis C/genetics; Hepatitis C/virology; Humans; Immunoenzyme Techniques; Immunosuppressive Agents/pharmacology; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation/genetics; Protein Conformation/drug effects; RNA, Messenger/genetics; RNA, Small Interfering/pharmacology; RNA, Viral/genetics; Replicon/genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Viral Nonstructural Proteins/genetics; Viral Nonstructural Proteins/immunology; Viral Nonstructural Proteins/metabolism; Virus Replication/drug effects