Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.

Gervais, Francois G; Sawyer, Nicole; Stocco, Rino; Hamel, Martine; Krawczyk, Connie; Sillaots, Susan; Denis, Danielle; Wong, Elizabeth; Wang, Zhaoyin; Gallant, Michel; Abraham, William M; Slipetz, Deborah; Crackower, Michael A; O'Neill, Gary P

Gervais, Francois G; Sawyer, Nicole; Stocco, Rino; Hamel, Martine; Krawczyk, Connie; Sillaots, Susan; Denis, Danielle; Wong, Elizabeth; Wang, Zhaoyin; Gallant, Michel; Abraham, William M; Slipetz, Deborah; Crackower, Michael A; O'Neill, Gary P.

Affiliation

Gervais FG; Department of Respiratory and Inflammation, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA. francois_gervais@merck.com

Mol Pharmacol ; 79(1): 69-76, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20943773

Subject(s)

Carbolines/chemistry; Carbolines/pharmacology; Receptors, Immunologic/antagonists & inhibitors; Receptors, Immunologic/biosynthesis; Receptors, Prostaglandin/antagonists & inhibitors; Receptors, Prostaglandin/biosynthesis; Th2 Cells/metabolism; Animals; Dogs; Gene Expression Regulation/drug effects; Gene Expression Regulation/immunology; HEK293 Cells; Humans; Macaca fascicularis; Mice; Platelet Aggregation Inhibitors/pharmacology; Protein Binding/immunology; Rats; Receptors, Immunologic/metabolism; Receptors, Immunologic/physiology; Receptors, Prostaglandin/metabolism; Receptors, Prostaglandin/physiology; Sheep; Species Specificity; Th2 Cells/drug effects

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Full text: 1 Database: MEDLINE Main subject: Receptors, Prostaglandin / Carbolines / Receptors, Immunologic / Th2 Cells Limits: Animals / Humans Language: En Year: 2011 Type: Article

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