Fertility in couples heterozygous for the tyrosinemia gene in Saguenay Lac-St-Jean.
Genet Couns
; 1(3-4): 259-64, 1990.
Article
in En
| MEDLINE
| ID: mdl-2098050
ABSTRACT
A case-control study of 84 couples from Saguenay-Lac-St-Jean, jointly heterozygous for the tyrosinemia gene, was done to determine whether the birth of an homozygous child affected their fertility rates. The mean number of children born to tyrosinemia and control couples between 1940 and 1986 was not different (p greater than 0.05). The knowledge that tyrosinemia was an autosomal recessive disorder, with risk of recurrence in these families, did not appear to modify reproductive behaviour. Fertility fell significantly in both the tyrosinemia and control families in the period of observation. This change reflects the decline in fertility of French Canadians in general during this period.
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Database:
MEDLINE
Main subject:
Tyrosine
/
Genetic Counseling
/
Amino Acid Metabolism, Inborn Errors
/
Genetic Carrier Screening
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Country/Region as subject:
America do norte
Language:
En
Year:
1990
Type:
Article