Dynamic origins of differential RNA binding function in two dsRBDs from the miRNA "microprocessor" complex.

Wostenberg, Christopher; Quarles, Kaycee A; Showalter, Scott A.

Affiliation

Wostenberg C; Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, Pennsylvania 16802, United States.

Biochemistry ; 49(50): 10728-36, 2010 Dec 21.

Article in En | MEDLINE | ID: mdl-21073201

Subject(s)

MicroRNAs/chemistry; MicroRNAs/metabolism; Amino Acid Sequence; Electrophoretic Mobility Shift Assay; Humans; Magnetic Resonance Spectroscopy; MicroRNAs/genetics; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Ribonuclease III/chemistry; Ribonuclease III/metabolism; Sequence Homology, Amino Acid