3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic.

Schiller, Radan; Tichotová, Lucie; Pavlík, Jan; Buchta, Vladimír; Melichar, Bohuslav; Votruba, Ivan; Kunes, Jirí; Spulák, Marcel; Pour, Milan

Schiller, Radan; Tichotová, Lucie; Pavlík, Jan; Buchta, Vladimír; Melichar, Bohuslav; Votruba, Ivan; Kunes, Jirí; Spulák, Marcel; Pour, Milan.

Affiliation

Schiller R; Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Hradec Králové, Czech Republic.

Bioorg Med Chem Lett ; 20(24): 7358-60, 2010 Dec 15.

Article in En | MEDLINE | ID: mdl-21074433

Subject(s)

Antifungal Agents/chemistry; Cytostatic Agents/chemistry; Furans/chemistry; Pyrans/chemistry; Animals; Antifungal Agents/chemical synthesis; Antifungal Agents/pharmacology; Cell Line, Tumor; Cytostatic Agents/chemical synthesis; Cytostatic Agents/pharmacology; Furans/chemical synthesis; Furans/pharmacology; Humans; Mice

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Pyrans / Cytostatic Agents / Furans / Antifungal Agents Limits: Animals / Humans Language: En Year: 2010 Type: Article

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Pyrans / Cytostatic Agents / Furans / Antifungal Agents Limits: Animals / Humans Language: En Year: 2010 Type: Article