Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans.

Corley, R A; Saghir, S A; Bartels, M J; Hansen, S C; Creim, J; McMartin, K E; Snellings, W M

Corley, R A; Saghir, S A; Bartels, M J; Hansen, S C; Creim, J; McMartin, K E; Snellings, W M.

Affiliation

Corley RA; Battelle Pacific Northwest Division, Richland, WA 99352, USA. rick.corley@pnl.gov

Toxicol Appl Pharmacol ; 250(3): 229-44, 2011 Feb 01.

Article in En | MEDLINE | ID: mdl-21074520

Subject(s)

Ethylene Glycol/pharmacokinetics; Glycolates/pharmacokinetics; Kidney Diseases/chemically induced; Oxalic Acid/metabolism; Animals; Calcium Oxalate/metabolism; Dose-Response Relationship, Drug; Drug Administration Routes; Ethylene Glycol/toxicity; Female; Glycolates/toxicity; Glyoxylates/metabolism; Humans; Kidney/drug effects; Kidney/metabolism; Male; Models, Biological; Rats; Rats, Wistar

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Full text: 1 Database: MEDLINE Main subject: Ethylene Glycol / Oxalic Acid / Glycolates / Kidney Diseases Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Year: 2011 Type: Article

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