Synthesis and biological evaluation of aryl-phospho-indole as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

Alexandre, François-René; Amador, Agnès; Bot, Stéphanie; Caillet, Catherine; Convard, Thierry; Jakubik, Jocelyn; Musiu, Chiara; Poddesu, Barbara; Vargiu, Luana; Liuzzi, Michel; Roland, Arlène; Seifer, Maria; Standring, David; Storer, Richard; Dousson, Cyril B

Alexandre, François-René; Amador, Agnès; Bot, Stéphanie; Caillet, Catherine; Convard, Thierry; Jakubik, Jocelyn; Musiu, Chiara; Poddesu, Barbara; Vargiu, Luana; Liuzzi, Michel; Roland, Arlène; Seifer, Maria; Standring, David; Storer, Richard; Dousson, Cyril B.

Affiliation

Alexandre FR; Laboratoires Idenix, Département de Chimie Médicinale, Montpellier, France. alexandre.francois-rene@idenix.com

J Med Chem ; 54(1): 392-5, 2011 Jan 13.

Article in En | MEDLINE | ID: mdl-21142105

Subject(s)

Anti-HIV Agents/chemical synthesis; HIV Reverse Transcriptase/metabolism; Indoles/chemical synthesis; Phosphinic Acids/chemical synthesis; Reverse Transcriptase Inhibitors/chemical synthesis; Animals; Anti-HIV Agents/pharmacokinetics; Anti-HIV Agents/pharmacology; Cell Line; Dogs; Drug Resistance, Viral; HIV Reverse Transcriptase/genetics; Haplorhini; Hepatocytes/metabolism; Humans; Indoles/pharmacokinetics; Indoles/pharmacology; Models, Molecular; Mutation; Phosphinic Acids/pharmacokinetics; Phosphinic Acids/pharmacology; Rats; Reverse Transcriptase Inhibitors/pharmacokinetics; Reverse Transcriptase Inhibitors/pharmacology; Solubility; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Phosphinic Acids / Reverse Transcriptase Inhibitors / Anti-HIV Agents / HIV Reverse Transcriptase / Indoles Limits: Animals / Humans Language: En Year: 2011 Type: Article

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