Dental considerations in the patient with Wilson's disease.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 111(1): 20-3, 2011 Jan.
Article
in En
| MEDLINE
| ID: mdl-21176821
ABSTRACT
Wilson's disease was described by Wilson in 1912. It is an autosomal recessive disorder caused by mutations in the ATP7B gene, a membrane-bound copper transporting ATPase. The deficiency of ATP7B protein impairs the biliary copper excretion, resulting in positive copper balance, hepatic copper accumulation, and copper toxicity from oxidant damage. The disease is a form of copper poisoning caused by a defect in the transport of copper that renders the patient unable to handle trace amounts of copper normally present in the diet and hence the clinical manifestations are those typically caused by copper toxicity and primarily involve the liver and the brain. Because effective treatment is available, it is important to make an early diagnosis. In this article, a review of clinical aspects of Wilson's disease, and its impact on dental management and dental considerations are discussed.
Full text:
1
Database:
MEDLINE
Main subject:
Dental Care for Chronically Ill
/
Hepatolenticular Degeneration
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Screening_studies
Limits:
Humans
Language:
En
Year:
2011
Type:
Article