Antimicrobial activity of ruthenium-based intercalators.
Eur J Pharm Sci
; 42(4): 313-7, 2011 Mar 18.
Article
in En
| MEDLINE
| ID: mdl-21182937
ABSTRACT
Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coli, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes.
Full text:
1
Database:
MEDLINE
Main subject:
Bacillus subtilis
/
Ruthenium Compounds
/
Methicillin-Resistant Staphylococcus aureus
/
Intercalating Agents
Limits:
Animals
Language:
En
Year:
2011
Type:
Article