Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation.

Sheikha, Ghassan Abu; Al-Sha'er, Mahmoud A; Taha, Mutasem O

Sheikha, Ghassan Abu; Al-Sha'er, Mahmoud A; Taha, Mutasem O.

Affiliation

Sheikha GA; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Zaytoonah Private University of Jordan, Amman, Jordan.

J Enzyme Inhib Med Chem ; 26(5): 603-9, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21190426

Subject(s)

Adenosine Triphosphatases/antagonists & inhibitors; HSP90 Heat-Shock Proteins/antagonists & inhibitors; HSP90 Heat-Shock Proteins/chemistry; Sulfonamides/pharmacology; Biological Assay; Coloring Agents/chemistry; Computer Simulation; Enzyme Activation/drug effects; Enzyme Inhibitors/pharmacology; HSP90 Heat-Shock Proteins/genetics; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Reproducibility of Results; Rosaniline Dyes/chemistry; Sulfaguanidine/chemistry; Sulfaguanidine/pharmacology; Sulfonamides/chemistry

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Sulfonamides / Adenosine Triphosphatases / HSP90 Heat-Shock Proteins Type of study: Prognostic_studies Limits: Humans Language: En Year: 2011 Type: Article

Fulltext

XML

PubMed Links

Search on Google