Structure and function of an irreversible agonist-ß(2) adrenoceptor complex.

Rosenbaum, Daniel M; Zhang, Cheng; Lyons, Joseph A; Holl, Ralph; Aragao, David; Arlow, Daniel H; Rasmussen, Søren G F; Choi, Hee-Jung; Devree, Brian T; Sunahara, Roger K; Chae, Pil Seok; Gellman, Samuel H; Dror, Ron O; Shaw, David E; Weis, William I; Caffrey, Martin; Gmeiner, Peter; Kobilka, Brian K

Rosenbaum, Daniel M; Zhang, Cheng; Lyons, Joseph A; Holl, Ralph; Aragao, David; Arlow, Daniel H; Rasmussen, Søren G F; Choi, Hee-Jung; Devree, Brian T; Sunahara, Roger K; Chae, Pil Seok; Gellman, Samuel H; Dror, Ron O; Shaw, David E; Weis, William I; Caffrey, Martin; Gmeiner, Peter; Kobilka, Brian K.

Affiliation

Rosenbaum DM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, USA.

Nature ; 469(7329): 236-40, 2011 Jan 13.

Article in En | MEDLINE | ID: mdl-21228876

Subject(s)

Adrenergic beta-2 Receptor Agonists/chemistry; Adrenergic beta-2 Receptor Agonists/metabolism; Receptors, Adrenergic, beta-2/chemistry; Receptors, Adrenergic, beta-2/metabolism; Crystallization; Crystallography, X-Ray; Disulfides/chemistry; Disulfides/metabolism; Drug Inverse Agonism; Heterotrimeric GTP-Binding Proteins/metabolism; Humans; Lipid Bilayers/chemistry; Lipid Bilayers/metabolism; Models, Molecular; Molecular Dynamics Simulation; Procaterol/chemistry; Procaterol/metabolism; Propanolamines/chemistry; Propanolamines/metabolism; Protein Conformation; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Viral Proteins/chemistry; Viral Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Receptors, Adrenergic, beta-2 / Adrenergic beta-2 Receptor Agonists Limits: Humans Language: En Year: 2011 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptors, Adrenergic, beta-2 / Adrenergic beta-2 Receptor Agonists Limits: Humans Language: En Year: 2011 Type: Article