Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).

Kuglstatter, Andreas; Mueller, Francis; Kusznir, Eric; Gsell, Bernard; Stihle, Martine; Thoma, Ralf; Benz, Joerg; Aspeslet, Launa; Freitag, Derrick; Hennig, Michael

Kuglstatter, Andreas; Mueller, Francis; Kusznir, Eric; Gsell, Bernard; Stihle, Martine; Thoma, Ralf; Benz, Joerg; Aspeslet, Launa; Freitag, Derrick; Hennig, Michael.

Affiliation

Kuglstatter A; F. Hoffmann-La Roche, Discovery Technologies, 4070 Basel, Switzerland.

Acta Crystallogr D Biol Crystallogr ; 67(Pt 2): 119-23, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21245533

Subject(s)

Cyclophilin A/chemistry; Cyclosporine/chemistry; Immunosuppressive Agents/chemistry; Crystallography, X-Ray; Cyclophilin A/metabolism; Cyclosporine/metabolism; Humans; Immunosuppressive Agents/metabolism; Isomerism; Models, Molecular; Protein Binding; Protein Structure, Tertiary

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Full text: 1 Database: MEDLINE Main subject: Cyclosporine / Cyclophilin A / Immunosuppressive Agents Limits: Humans Language: En Year: 2011 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Cyclosporine / Cyclophilin A / Immunosuppressive Agents Limits: Humans Language: En Year: 2011 Type: Article