Successfully treated multicentric Castleman's disease with renal thrombotic microangiopathy using rituximab and corticosteroid.
Clin Nephrol
; 75(2): 165-70, 2011 Feb.
Article
in En
| MEDLINE
| ID: mdl-21255547
ABSTRACT
Thrombotic microangiopathy (TMA) is a rare renal complication accompanied with Castleman's disease. We report the first case of TMA combined plasma cell type multicentric Castleman's disease (MCD) which was successfully treated with rituximab and corticosteroid. A previously healthy 60-year-old Korean man was admitted due to acute renal failure, thrombocytopenia, and multiple lymphadenopathies. The result of lymph node biopsy was plasma cell type Castleman's disease and TMA was revealed by kidney biopsy. After treatment with rituximab, prednisolone and temporary hemodialysis, complete remission was achieved. The combination of corticosteroid and rituximab was associated with improvement for this patient.
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Database:
MEDLINE
Main subject:
Castleman Disease
/
Adrenal Cortex Hormones
/
Thrombotic Microangiopathies
/
Antibodies, Monoclonal, Murine-Derived
/
Immunologic Factors
/
Kidney Diseases
Type of study:
Diagnostic_studies
/
Etiology_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Year:
2011
Type:
Article