Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART.
Clin Immunol
; 139(1): 32-9, 2011 Apr.
Article
in En
| MEDLINE
| ID: mdl-21296026
ABSTRACT
Some HIV/hepatitis C virus co-infected patients beginning ART experience Immune Restoration Disease (IRD) manifested as a rise in serum alanine transaminase. This was investigated in HIV/HCV co-infected individuals (n=50) commencing ART in Jakarta (Indonesia). Samples were collected at weeks 0, 4, 8, 12, 24 and at HCV IRD. Nine patients experienced HCV IRD (incidence=9.2 per 1000 person-weeks). These resolved without changing treatment. Markers of T-cell activation (sCD26, sCD30) and immune recruitment (CXCL10) increased in many HCV IRD cases, so T-cells may mediate HCV IRD. Total anti-HCV antibody (core, NS3, NS4) remained lower in HCV IRD cases, but levels of antibody to core were not lower in HCV IRD cases. Rises in HCV RNA on ART were independent of HCV IRD, but there was a negative correlation between baseline HCV RNA and total anti-HCV antibody. High levels of antibody may protect against HCV IRD, via lower HCV antigen loads.
Full text:
1
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
T-Lymphocytes
/
HIV Infections
/
Hepatitis C
/
Anti-HIV Agents
/
Immune Reconstitution Inflammatory Syndrome
Type of study:
Etiology_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Year:
2011
Type:
Article