An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics.

Hutinec, Antun; Rupcic, Renata; Ziher, Dinko; Smith, Kirsten S; Milhous, Wilbur; Ellis, William; Ohrt, Colin; Schönfeld, Zrinka Ivezic

Hutinec, Antun; Rupcic, Renata; Ziher, Dinko; Smith, Kirsten S; Milhous, Wilbur; Ellis, William; Ohrt, Colin; Schönfeld, Zrinka Ivezic.

Affiliation

Hutinec A; GlaxoSmithKline Research Centre Zagreb Ltd, Zagreb, Croatia. antun.hutinec@glpg.com

Bioorg Med Chem ; 19(5): 1692-701, 2011 Mar 01.

Article in En | MEDLINE | ID: mdl-21316974

Subject(s)

Antimalarials/chemical synthesis; Plasmodium falciparum/drug effects; Thiourea/chemical synthesis; Urea/chemical synthesis; Antimalarials/chemistry; Antimalarials/pharmacology; Automation; Azithromycin/pharmacology; Drug Resistance, Multiple; Inhibitory Concentration 50; Macrolides/pharmacology; Molecular Structure; Structure-Activity Relationship; Thiourea/chemistry; Thiourea/pharmacology; Urea/chemistry; Urea/pharmacology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Thiourea / Urea / Antimalarials Language: En Year: 2011 Type: Article

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Plasmodium falciparum / Thiourea / Urea / Antimalarials Language: En Year: 2011 Type: Article