Transcriptional regulation of the human telomerase reverse transcriptase: new insights.

Chebel, Amel; Ffrench, Martine

Chebel, Amel; Ffrench, Martine.

Affiliation

Chebel A; Université Claude Bernard - UMR, Oullins, France.

Transcription ; 1(1): 27-31, 2010.

Article in En | MEDLINE | ID: mdl-21327156

ABSTRACT

ABSTRACT

hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for therapeutic developments.

Subject(s)

Gene Expression Regulation; Telomerase/metabolism; Transcription, Genetic; Animals; Humans; Lymphocyte Activation; Metabolic Networks and Pathways; NFATC Transcription Factors/metabolism

Key words

NFAT; cell stimulation; hTERT; immunosuppression; tumorigenesis

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Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Gene Expression Regulation / Telomerase Limits: Animals / Humans Language: En Year: 2010 Type: Article

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