Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.

Colado, Enrique; Paíno, Teresa; Maiso, Patricia; Ocio, Enrique M; Chen, Xi; Alvarez-Fernández, Stela; Gutiérrez, Norma C; Martín-Sánchez, Jesús; Flores-Montero, Juan; San Segundo, Laura; Garayoa, Mercedes; Fernández-Lázaro, Diego; Vidriales, Maria-Belen; Galmarini, Carlos M; Avilés, Pablo; Cuevas, Carmen; Pandiella, Atanasio; San-Miguel, Jesús F

Colado, Enrique; Paíno, Teresa; Maiso, Patricia; Ocio, Enrique M; Chen, Xi; Alvarez-Fernández, Stela; Gutiérrez, Norma C; Martín-Sánchez, Jesús; Flores-Montero, Juan; San Segundo, Laura; Garayoa, Mercedes; Fernández-Lázaro, Diego; Vidriales, Maria-Belen; Galmarini, Carlos M; Avilés, Pablo; Cuevas, Carmen; Pandiella, Atanasio; San-Miguel, Jesús F.

Affiliation

Colado E; Centro de Investigación del Cáncer, IBMCC/CSIC-Universidad de Salamanca, Salamanca, Spain.

Haematologica ; 96(5): 687-95, 2011 May.

Article in En | MEDLINE | ID: mdl-21330323

Subject(s)

DNA Breaks, Double-Stranded/drug effects; DNA Damage; Stem Cells/drug effects; Tetrahydroisoquinolines/pharmacology; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; BRCA1 Protein/genetics; BRCA1 Protein/metabolism; Blotting, Western; Caspases/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Leukemic/drug effects; HL-60 Cells; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/pathology; Mitochondria/drug effects; Mitochondria/metabolism; Oligonucleotide Array Sequence Analysis; Rad51 Recombinase/genetics; Rad51 Recombinase/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells/metabolism; Stem Cells/pathology; Tumor Cells, Cultured

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Full text: 1 Database: MEDLINE Main subject: Stem Cells / DNA Damage / Tetrahydroisoquinolines / DNA Breaks, Double-Stranded Limits: Humans Language: En Year: 2011 Type: Article

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