Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-&#954;B mediated and supports innate and adaptive anti-tumour immune priming.

Steele, Lynette; Errington, Fiona; Prestwich, Robin; Ilett, Elizabeth; Harrington, Kevin; Pandha, Hardev; Coffey, Matt; Selby, Peter; Vile, Richard; Melcher, Alan

Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming.

Steele, Lynette; Errington, Fiona; Prestwich, Robin; Ilett, Elizabeth; Harrington, Kevin; Pandha, Hardev; Coffey, Matt; Selby, Peter; Vile, Richard; Melcher, Alan.

Affiliation

Steele L; Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

Mol Cancer ; 10: 20, 2011 Feb 21.

Article in En | MEDLINE | ID: mdl-21338484

Subject(s)

Chemokines/biosynthesis; Immunity/immunology; Inflammation Mediators/metabolism; Melanoma/immunology; NF-kappa B/metabolism; Reoviridae/immunology; eIF-2 Kinase/metabolism; Adaptive Immunity/drug effects; Adaptive Immunity/immunology; Cell Line, Tumor; Chemokines/metabolism; Chemotaxis/drug effects; Culture Media, Conditioned/pharmacology; Dendritic Cells/cytology; Dendritic Cells/drug effects; Dendritic Cells/immunology; Humans; Immunity/drug effects; Immunity, Innate/drug effects; Immunity, Innate/immunology; Killer Cells, Natural/cytology; Killer Cells, Natural/drug effects; Killer Cells, Natural/immunology; Lymphocyte Activation/drug effects; Melanoma/enzymology; Melanoma/metabolism; Melanoma/virology; Phenotype; Reoviridae/drug effects; Reoviridae Infections/immunology; T-Lymphocytes, Cytotoxic/cytology; T-Lymphocytes, Cytotoxic/drug effects; T-Lymphocytes, Cytotoxic/immunology

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Full text: 1 Database: MEDLINE Main subject: Reoviridae / NF-kappa B / Inflammation Mediators / Chemokines / EIF-2 Kinase / Immunity / Melanoma Limits: Humans Language: En Year: 2011 Type: Article

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