Inhibition of 3,4-methylenedioxymethamphetamine metabolism leads to marked decrease in 3,4-dihydroxymethamphetamine formation but no change in serotonin neurotoxicity: implications for mechanisms of neurotoxicity.

Mueller, Melanie; Yuan, Jie; Maldonado Adrian, Concepcion; McCann, Una D; Ricaurte, George A

Mueller, Melanie; Yuan, Jie; Maldonado Adrian, Concepcion; McCann, Una D; Ricaurte, George A.

Affiliation

Mueller M; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21224, USA.

Synapse ; 65(10): 983-90, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21360595

Subject(s)

3,4-Methylenedioxyamphetamine/analogs & derivatives; Deoxyepinephrine/analogs & derivatives; Neurotoxicity Syndromes/metabolism; Neurotoxins/toxicity; Serotonin/toxicity; 3,4-Methylenedioxyamphetamine/antagonists & inhibitors; 3,4-Methylenedioxyamphetamine/pharmacokinetics; 3,4-Methylenedioxyamphetamine/toxicity; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/metabolism; Deoxyepinephrine/antagonists & inhibitors; Deoxyepinephrine/pharmacokinetics; Deoxyepinephrine/toxicity; Dextromethorphan/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Hydroxyindoleacetic Acid/metabolism; Male; Neurotoxins/metabolism; Rats; Rats, Sprague-Dawley; Serotonin/metabolism; Sulfides/chemistry; Sulfides/metabolism

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Full text: 1 Database: MEDLINE Main subject: Serotonin / Neurotoxicity Syndromes / Deoxyepinephrine / 3,4-Methylenedioxyamphetamine / Neurotoxins Limits: Animals Language: En Year: 2011 Type: Article

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