Interferon-&#945;-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.

Santini, Stefano M; Lapenta, Caterina; Donati, Simona; Spadaro, Francesca; Belardelli, Filippo; Ferrantini, Maria

Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.

Santini, Stefano M; Lapenta, Caterina; Donati, Simona; Spadaro, Francesca; Belardelli, Filippo; Ferrantini, Maria.

Affiliation

Santini SM; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

PLoS One ; 6(2): e17364, 2011 Feb 28.

Article in En | MEDLINE | ID: mdl-21387004

Subject(s)

Interferon-alpha/pharmacology; Interleukin-12/physiology; Interleukin-23/physiology; Monocytes/drug effects; Th1 Cells/physiology; Th17 Cells/immunology; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/physiology; Cell Differentiation/drug effects; Cell Polarity/drug effects; Cells, Cultured; Culture Media, Conditioned/pharmacology; Dendritic Cells/drug effects; Dendritic Cells/metabolism; Dendritic Cells/physiology; Humans; Interleukin-12/metabolism; Interleukin-23/metabolism; Lymphocyte Activation/drug effects; Lymphocyte Activation/physiology; Models, Biological; Monocytes/metabolism; Monocytes/physiology; Th1 Cells/drug effects; Th17 Cells/metabolism; Th17 Cells/physiology; Th17 Cells/transplantation

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Full text: 1 Database: MEDLINE Main subject: Monocytes / Interferon-alpha / Th1 Cells / Interleukin-12 / Interleukin-23 / Th17 Cells Type of study: Prognostic_studies Limits: Humans Language: En Year: 2011 Type: Article

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