ADAM12 induces estrogen-independence in breast cancer cells.

Roy, Roopali; Moses, Marsha A

Roy, Roopali; Moses, Marsha A.

Affiliation

Roy R; The Program in Vascular Biology, Department of Surgery, 12.214, Karp Research Building, Children's Hospital, Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Breast Cancer Res Treat ; 131(3): 731-41, 2012 Feb.

Article in En | MEDLINE | ID: mdl-21387162

Subject(s)

ADAM Proteins/metabolism; Breast Neoplasms/enzymology; Estrogens/metabolism; Membrane Proteins/metabolism; ADAM Proteins/genetics; ADAM12 Protein; Amphiregulin; Antineoplastic Agents, Hormonal/pharmacology; Breast Neoplasms/genetics; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm/genetics; EGF Family of Proteins; ErbB Receptors/antagonists & inhibitors; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Glycoproteins/metabolism; Humans; Intercellular Signaling Peptides and Proteins/metabolism; Isoenzymes/genetics; Isoenzymes/metabolism; Membrane Proteins/genetics; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Protein Kinase Inhibitors/pharmacology; Receptors, Estrogen/antagonists & inhibitors; Signal Transduction/drug effects; Tamoxifen/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / ADAM Proteins / Estrogens / Membrane Proteins Limits: Female / Humans Language: En Year: 2012 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / ADAM Proteins / Estrogens / Membrane Proteins Limits: Female / Humans Language: En Year: 2012 Type: Article