A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.

Torti, Davide; Sassi, Francesco; Galimi, Francesco; Gastaldi, Stefania; Perera, Timothy; Comoglio, Paolo M; Trusolino, Livio; Bertotti, Andrea

Torti, Davide; Sassi, Francesco; Galimi, Francesco; Gastaldi, Stefania; Perera, Timothy; Comoglio, Paolo M; Trusolino, Livio; Bertotti, Andrea.

Affiliation

Torti D; Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo, Torino, Italy.

Int J Cancer ; 130(6): 1357-66, 2012 Mar 15.

Article in En | MEDLINE | ID: mdl-21500189

Subject(s)

Biomarkers, Tumor/metabolism; Proto-Oncogene Proteins c-met/antagonists & inhibitors; Stomach Neoplasms/drug therapy; Stomach Neoplasms/metabolism; Animals; Biomarkers, Tumor/blood; Biomarkers, Tumor/genetics; Cell Line, Tumor; Chemokine CXCL1/blood; Chemokine CXCL1/genetics; Chemokine CXCL1/metabolism; Female; Gene Expression Profiling; Humans; Indoles/pharmacology; Interleukin-6/blood; Interleukin-6/genetics; Interleukin-6/metabolism; Interleukin-8/blood; Interleukin-8/genetics; Interleukin-8/metabolism; Mannose-Binding Lectins/blood; Mannose-Binding Lectins/genetics; Mannose-Binding Lectins/metabolism; Membrane Glycoproteins/blood; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Nude; Proteomics; Proto-Oncogene Proteins c-met/genetics; Proto-Oncogene Proteins c-met/metabolism; Receptors, Cell Surface/blood; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Stomach Neoplasms/blood; Stomach Neoplasms/genetics; Sulfones/pharmacology; Xenograft Model Antitumor Assays

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Stomach Neoplasms / Biomarkers, Tumor / Proto-Oncogene Proteins c-met Type of study: Prognostic_studies Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google