Synthesis of tetrahydronaphthalene lignan esters by intramolecular cyclization of ethyl p-azidophenyl-2-phenylalkanoates and evaluation of the growth inhibition of human tumor cell lines.

Pinto, Orlando; Sardinha, João; Vaz, Pedro D; Piedade, Fátima; Calhorda, Maria J; Abramovitch, Rudolph; Nazareth, Nair; Pinto, Madalena; Nascimento, Maria S J; Rauter, Amélia P

Pinto, Orlando; Sardinha, João; Vaz, Pedro D; Piedade, Fátima; Calhorda, Maria J; Abramovitch, Rudolph; Nazareth, Nair; Pinto, Madalena; Nascimento, Maria S J; Rauter, Amélia P.

Affiliation

Pinto O; Universidade de Lisboa, Faculdade de Ciências, Centro de Química e Bioquímica/Departamento de Química e Bioquímica (CQB/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal.

J Med Chem ; 54(9): 3175-87, 2011 May 12.

Article in En | MEDLINE | ID: mdl-21504224

Subject(s)

Antineoplastic Agents/chemical synthesis; Azides/chemical synthesis; Lignans/chemical synthesis; Spiro Compounds/chemical synthesis; Tetrahydronaphthalenes/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Azides/chemistry; Azides/pharmacology; Cell Line, Tumor; Cell Proliferation/drug effects; Crystallography, X-Ray; Cyclization; Drug Screening Assays, Antitumor; Esters; Humans; Lignans/chemistry; Lignans/pharmacology; Models, Molecular; Spiro Compounds/chemistry; Spiro Compounds/pharmacology; Structure-Activity Relationship; Tetrahydronaphthalenes/chemistry; Tetrahydronaphthalenes/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Spiro Compounds / Azides / Tetrahydronaphthalenes / Lignans / Antineoplastic Agents Limits: Humans Language: En Year: 2011 Type: Article

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