MMP-13 selective &#945;-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres.

Barta, Thomas E; Becker, Daniel P; Bedell, Louis J; Easton, Alan M; Hockerman, Susan L; Kiefer, James; Munie, Grace E; Mathis, Karl J; Li, Madeleine H; Rico, Joseph G; Villamil, Clara I; Williams, Jennifer M

MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres.

Barta, Thomas E; Becker, Daniel P; Bedell, Louis J; Easton, Alan M; Hockerman, Susan L; Kiefer, James; Munie, Grace E; Mathis, Karl J; Li, Madeleine H; Rico, Joseph G; Villamil, Clara I; Williams, Jennifer M.

Affiliation

Barta TE; Department of Medicinal Chemistry, Pfizer Research & Development, 4901 Searle Parkway, Skokie, IL 60077, USA. thomas_e_barta@yahoo.com

Bioorg Med Chem Lett ; 21(10): 2820-2, 2011 May 15.

Article in En | MEDLINE | ID: mdl-21507637

Subject(s)

Amides/chemical synthesis; Enzyme Inhibitors/chemical synthesis; Heterocyclic Compounds/chemical synthesis; Hydroxamic Acids/chemical synthesis; Matrix Metalloproteinase Inhibitors; Sulfones/chemical synthesis; Amides/chemistry; Animals; Crystallography, X-Ray; Enzyme Inhibitors/chemistry; Heterocyclic Compounds/chemistry; Hydroxamic Acids/chemistry; Matrix Metalloproteinase 13/chemistry; Models, Molecular; Rats; Structure-Activity Relationship; Substrate Specificity; Sulfones/chemistry

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Full text: 1 Database: MEDLINE Main subject: Sulfones / Enzyme Inhibitors / Matrix Metalloproteinase Inhibitors / Amides / Heterocyclic Compounds / Hydroxamic Acids Limits: Animals Language: En Year: 2011 Type: Article

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