Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis.

Sabo-Attwood, Tara; Ramos-Nino, Maria E; Eugenia-Ariza, Maria; Macpherson, Maximilian B; Butnor, Kelly J; Vacek, Pamela C; McGee, Sean P; Clark, Jessica C; Steele, Chad; Mossman, Brooke T

Sabo-Attwood, Tara; Ramos-Nino, Maria E; Eugenia-Ariza, Maria; Macpherson, Maximilian B; Butnor, Kelly J; Vacek, Pamela C; McGee, Sean P; Clark, Jessica C; Steele, Chad; Mossman, Brooke T.

Affiliation

Sabo-Attwood T; Department of Environmental Health Sciences and NanoCenter, University of South Carolina, Columbia, South Carolina, USA. sabo@phhp.ufl.edu

Am J Pathol ; 178(5): 1975-85, 2011 May.

Article in En | MEDLINE | ID: mdl-21514415

Subject(s)

Asbestosis/metabolism; Gene Expression Profiling; Inflammation/metabolism; Mucins/biosynthesis; Osteopontin/metabolism; Animals; Asbestos, Serpentine/adverse effects; Asbestosis/genetics; Asbestosis/pathology; Bronchioles/immunology; Bronchioles/metabolism; Bronchioles/pathology; Bronchoalveolar Lavage; Disease Models, Animal; Inflammation/genetics; Inflammation/pathology; Lasers; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdissection; Osteopontin/genetics; Respiratory Mucosa/immunology; Respiratory Mucosa/metabolism; Respiratory Mucosa/pathology; Up-Regulation

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Full text: 1 Database: MEDLINE Main subject: Asbestosis / Gene Expression Profiling / Osteopontin / Inflammation / Mucins Type of study: Prognostic_studies Limits: Animals Language: En Year: 2011 Type: Article

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