Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.

Mody, N; Agouni, A; McIlroy, G D; Platt, B; Delibegovic, M

Mody, N; Agouni, A; McIlroy, G D; Platt, B; Delibegovic, M.

Affiliation

Mody N; Institute of Biological & Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, Scotland, UK.

Diabetologia ; 54(8): 2143-51, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21538175

Subject(s)

Alzheimer Disease/metabolism; Amyloid beta-Protein Precursor/metabolism; Glucose Intolerance/physiopathology; Obesity/metabolism; Presenilin-1/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism; Retinol-Binding Proteins, Plasma/metabolism; Ribosomal Protein S6/metabolism; Alzheimer Disease/genetics; Amyloid beta-Protein Precursor/genetics; Animals; Body Weight/genetics; Body Weight/physiology; Brain/metabolism; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Mice; Mice, Transgenic; Obesity/chemically induced; Phosphorylation; Presenilin-1/genetics

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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / Glucose Intolerance / Ribosomal Protein S6 / Presenilin-1 / Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Retinol-Binding Proteins, Plasma / Alzheimer Disease / Obesity Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2011 Type: Article

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