Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging.
NMR Biomed
; 24(10): 1343-52, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-21538635
ABSTRACT
In the present study, a balanced steady-state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized (129) Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, (129) Xe lung images in end-inspiratory and end-expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase-induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase-treated mice.
Full text:
1
Database:
MEDLINE
Main subject:
Respiration
/
Xenon
/
Magnetic Resonance Imaging
/
Lung
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Year:
2011
Type:
Article