T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

Manz, Boryana N; Jackson, Bryan L; Petit, Rebecca S; Dustin, Michael L; Groves, Jay

Manz, Boryana N; Jackson, Bryan L; Petit, Rebecca S; Dustin, Michael L; Groves, Jay.

Affiliation

Manz BN; Howard Hughes Medical Institute, Department of Chemistry, and Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA.

Proc Natl Acad Sci U S A ; 108(22): 9089-94, 2011 May 31.

Article in En | MEDLINE | ID: mdl-21576490

Subject(s)

Receptors, Antigen, T-Cell/immunology; T-Lymphocytes/immunology; Animals; Biophysics/methods; CD4-Positive T-Lymphocytes/cytology; Calcium/metabolism; Calcium Signaling; Immune System; Intercellular Adhesion Molecule-1/metabolism; Ligands; Lipid Bilayers/chemistry; Lipids/chemistry; Lymphocyte Activation; Major Histocompatibility Complex; Mice

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / T-Lymphocytes Limits: Animals Language: En Year: 2011 Type: Article

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / T-Lymphocytes Limits: Animals Language: En Year: 2011 Type: Article