An alternative to animal testing in the quality control of erythropoietin.

Zimmermann, H; Gerhard, D; Hothorn, L A; Dingermann, T

Zimmermann, H; Gerhard, D; Hothorn, L A; Dingermann, T.

Affiliation

Zimmermann H; Roche Diagnostics GmbH, Bioassays, Sandhoferstrasse 116, 68305 Mannheim. hanne.zimmermann@roche.com

Pharmeur Bio Sci Notes ; 2011(1): 66-80, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21619857

Subject(s)

Animal Testing Alternatives; Electrophoresis, Capillary; Erythropoietin/analysis; Hematinics/analysis; Amino Acid Sequence; Animal Testing Alternatives/methods; Animal Testing Alternatives/standards; Animals; Anion Exchange Resins; Biological Assay; Chromatography, Ion Exchange; Erythropoietin/chemistry; Erythropoietin/pharmacology; Erythropoietin/standards; Glycosylation; Hematinics/chemistry; Hematinics/pharmacology; Hematinics/standards; Hematopoiesis/drug effects; Linear Models; Mice; Models, Biological; Molecular Sequence Data; Principal Component Analysis; Protein Conformation; Protein Isoforms; Quality Control; Recombinant Proteins; Reproducibility of Results; Sialic Acids/analysis; Surface Plasmon Resonance

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Database: MEDLINE Main subject: Erythropoietin / Electrophoresis, Capillary / Hematinics / Animal Testing Alternatives Type of study: Prognostic_studies Limits: Animals Language: En Year: 2011 Type: Article

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