Identification and quantification of glutathione adducts of clozapine using ultra-high-performance liquid chromatography with orthogonal acceleration time-of-flight mass spectrometry and inductively coupled plasma mass spectrometry.

MacDonald, Cathy; Smith, Christopher; Michopoulos, Filippos; Weaver, Richard; Wilson, Ian D

MacDonald, Cathy; Smith, Christopher; Michopoulos, Filippos; Weaver, Richard; Wilson, Ian D.

Affiliation

MacDonald C; Discovery DMPK, AstraZeneca R&D, Charnwood, Loughborough, Leicestershire LE11 5RH, UK.

Rapid Commun Mass Spectrom ; 25(13): 1787-93, 2011 Jul 15.

Article in En | MEDLINE | ID: mdl-21638353

Subject(s)

Chromatography, High Pressure Liquid/methods; Clozapine/analysis; Glutathione/analysis; Tandem Mass Spectrometry/methods; Clozapine/chemistry; Glutathione/chemistry; Humans; Microsomes, Liver/metabolism; Sensitivity and Specificity; Solid Phase Extraction; Sulfur

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Full text: 1 Database: MEDLINE Main subject: Chromatography, High Pressure Liquid / Clozapine / Tandem Mass Spectrometry / Glutathione Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2011 Type: Article

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