Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration.

Pons, Marianne; Cousins, Scott W; Alcazar, Oscar; Striker, Gary E; Marin-Castaño, Maria E

Pons, Marianne; Cousins, Scott W; Alcazar, Oscar; Striker, Gary E; Marin-Castaño, Maria E.

Affiliation

Pons M; Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.

Am J Pathol ; 178(6): 2665-81, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21641389

Subject(s)

Angiotensin II/pharmacology; Basigin/metabolism; Matrix Metalloproteinase 14/metabolism; Matrix Metalloproteinase 2/metabolism; Mitogen-Activated Protein Kinase 1/metabolism; Receptor, Angiotensin, Type 1/metabolism; Retinal Pigment Epithelium/enzymology; Animals; Blood Pressure/drug effects; Cell Line; Enzyme Activation/drug effects; Gene Silencing/drug effects; Hypertension/complications; Hypertension/physiopathology; JNK Mitogen-Activated Protein Kinases/metabolism; MAP Kinase Signaling System/drug effects; Macular Degeneration/blood; Macular Degeneration/complications; Macular Degeneration/enzymology; Macular Degeneration/pathology; Mice; Mice, Inbred C57BL; Phosphorylation/drug effects; Renin/blood; Retinal Pigment Epithelium/drug effects; Retinal Pigment Epithelium/pathology; Systole/drug effects; Up-Regulation/drug effects; p38 Mitogen-Activated Protein Kinases

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Full text: 1 Database: MEDLINE Main subject: Angiotensin II / Mitogen-Activated Protein Kinase 1 / Matrix Metalloproteinase 2 / Receptor, Angiotensin, Type 1 / Basigin / Matrix Metalloproteinase 14 / Retinal Pigment Epithelium Type of study: Risk_factors_studies Limits: Animals Language: En Year: 2011 Type: Article

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