Design driven HtL: The discovery and synthesis of new high efficacy ß2-agonists.
Bioorg Med Chem Lett
; 21(13): 4027-31, 2011 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-21652207
ABSTRACT
The design and synthesis of a new series of high efficacy ß(2)-agonists devoid of the key benzylic alcohol present in previously described highly efficacious ß(2)-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of ß(2)-adrenoceptor crystal structure, other biophysical data and modeling studies.
Full text:
1
Database:
MEDLINE
Main subject:
Drug Design
/
Adrenergic beta-2 Receptor Agonists
Limits:
Animals
/
Humans
Language:
En
Year:
2011
Type:
Article