Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.

Clement, Mathew; Ladell, Kristin; Ekeruche-Makinde, Julia; Miles, John J; Edwards, Emily S J; Dolton, Garry; Williams, Tamsin; Schauenburg, Andrea J A; Cole, David K; Lauder, Sarah N; Gallimore, Awen M; Godkin, Andrew J; Burrows, Scott R; Price, David A; Sewell, Andrew K; Wooldridge, Linda

Clement, Mathew; Ladell, Kristin; Ekeruche-Makinde, Julia; Miles, John J; Edwards, Emily S J; Dolton, Garry; Williams, Tamsin; Schauenburg, Andrea J A; Cole, David K; Lauder, Sarah N; Gallimore, Awen M; Godkin, Andrew J; Burrows, Scott R; Price, David A; Sewell, Andrew K; Wooldridge, Linda.

Affiliation

Clement M; Cardiff University School of Medicine, University Hospital, Cardiff CF14 4XN, United Kingdom.

J Immunol ; 187(2): 654-63, 2011 Jul 15.

Article in En | MEDLINE | ID: mdl-21677135

Subject(s)

Antibodies/physiology; CD8 Antigens/immunology; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; Cytotoxicity, Immunologic; HLA-A Antigens/chemistry; Peptides/chemistry; Receptors, Antigen, T-Cell/deficiency; Antibodies/metabolism; CD8-Positive T-Lymphocytes/cytology; Clone Cells; HLA-A Antigens/immunology; HLA-A2 Antigen; Humans; Immunophenotyping; Ligands; Peptides/analysis; Peptides/immunology; Receptors, Antigen, T-Cell/immunology; Receptors, Antigen, T-Cell/metabolism; Signal Transduction/immunology; Staining and Labeling; Surface Plasmon Resonance

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Full text: 1 Database: MEDLINE Main subject: Peptides / Receptors, Antigen, T-Cell / HLA-A Antigens / CD8 Antigens / CD8-Positive T-Lymphocytes / Cytotoxicity, Immunologic / Antibodies Limits: Humans Language: En Year: 2011 Type: Article

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