Discovery of indazoles as inhibitors of Tpl2 kinase.

Hu, Yonghan; Cole, Derek; Denny, Rajiah Aldrin; Anderson, David R; Ipek, Manus; Ni, Yike; Wang, Xiaolun; Thaisrivongs, Suvit; Chamberlain, Timothy; Hall, J Perry; Liu, Julie; Luong, Michael; Lin, Lih-Ling; Telliez, Jean-Baptiste; Gopalsamy, Ariamala

Hu, Yonghan; Cole, Derek; Denny, Rajiah Aldrin; Anderson, David R; Ipek, Manus; Ni, Yike; Wang, Xiaolun; Thaisrivongs, Suvit; Chamberlain, Timothy; Hall, J Perry; Liu, Julie; Luong, Michael; Lin, Lih-Ling; Telliez, Jean-Baptiste; Gopalsamy, Ariamala.

Affiliation

Hu Y; Worldwide Medicinal Chemistry, Pfizer Global Research and Development, 200 CambridgePark Drive, Cambridge, MA 02140, USA.

Bioorg Med Chem Lett ; 21(16): 4758-61, 2011 Aug 15.

Article in En | MEDLINE | ID: mdl-21742493

Subject(s)

Drug Discovery; Enzyme Inhibitors/pharmacology; Indazoles/pharmacology; MAP Kinase Kinase Kinases/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Humans; Indazoles/chemical synthesis; Indazoles/chemistry; MAP Kinase Kinase Kinases/metabolism; Models, Molecular; Molecular Structure; Monocytes/enzymology; Monocytes/metabolism; Proto-Oncogene Proteins/metabolism; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins / MAP Kinase Kinase Kinases / Enzyme Inhibitors / Drug Discovery / Indazoles Limits: Humans Language: En Year: 2011 Type: Article

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