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Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.
Deriziotis, Pelagia; André, Ralph; Smith, David M; Goold, Rob; Kinghorn, Kerri J; Kristiansen, Mark; Nathan, James A; Rosenzweig, Rina; Krutauz, Dasha; Glickman, Michael H; Collinge, John; Goldberg, Alfred L; Tabrizi, Sarah J.
Affiliation
  • Deriziotis P; Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK.
EMBO J ; 30(15): 3065-77, 2011 Jul 08.
Article in En | MEDLINE | ID: mdl-21743439

Full text: 1 Database: MEDLINE Main subject: PrPSc Proteins / Protein Interaction Mapping / Proteasome Inhibitors Limits: Animals / Humans Language: En Year: 2011 Type: Article

Full text: 1 Database: MEDLINE Main subject: PrPSc Proteins / Protein Interaction Mapping / Proteasome Inhibitors Limits: Animals / Humans Language: En Year: 2011 Type: Article